Journal article
Lynch syndrome and cervical cancer
YC Antill, JG Dowty, AK Win, T Thompson, MD Walsh, MC Cummings, S Gallinger, NM Lindor, L Le Marchand, JL Hopper, PA Newcomb, RW Haile, J Church, KM Tucker, DD Buchanan, JP Young, IM Winship, MA Jenkins
International Journal of Cancer | WILEY | Published : 2015
DOI: 10.1002/ijc.29641
Abstract
Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 MLH1, 174 MSH2, 35 MSH6 and 27 PMS2) were ascertained via population cancer registries or via family cancer clinics in Australia, New Zealand, Canada, and USA. Personal and family histories of cancer were obtained from participant interviews. Modified segregation analysis was used to estimate the hazard ratio (incidence rates for car..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
Grant sponsor: National Cancer Institute, National Institutes of Health (NIH); UM1 CA167551; Grant awardee: Australasian Colorectal Cancer Family Registry; U01/U24 CA097735; Grant awardee: Mayo Clinic Cooperative Family Registry for Colon Cancer Studies; Grant number: U01/U24 CA074800; Grant awardee: Ontario Familial Colorectal Cancer Registry; U01/U24 CA074783; Grant awardee: Seattle Colorectal Cancer Family Registry; U01/U24 CA074794; Grant awardee: Stanford Consortium Colorectal Cancer Family Registry; U01/U24 CA074799; Grant awardee: University of Hawaii Colorectal Cancer Family Registry; Grant number: U01/U24 CA074806; Grant sponsors: Royal Australasian College of Physicians, Servier Staff Scholarship, Victorian Cancer Agency Early Career Seed Grant.